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KMID : 1123920020160061201
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 6 p.1201 ~ p.1206
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Studies on the SNPs and Haplotype of Cytochrome P450 gene in Tae-eum, So-yang and So-eum persons
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Park Jong-Oh
Lim Nam-Kyu
Lee Yong-Heun
Chae Heui-Jin
Namgung Uk
Kim Dong-Hee
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Abstract
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oriental medicine, human being is classified into four groups according to their body constitution status (;tae-yang, tae-eum, so-yang, and so-eum persons) considering the differences in function of internal organs and characteristics. Four body constitution, called ’sa-sang’ has been recognized as an important factor for diagnosing the patients before madical teratment. Yet, the criteria to divide body constitutions or its scientific principle are not clearly defined. As an initial effort to elucidate biological priciples underlying four body constitution groups, we studied genetic variations among three constitution groups (tae-eum, so-yang, and so-eum persons). Noting distinct responses to ingested food and administered drugs among three groups, SNPs and haplotype experiments were performed in 2D6, 2C9, and 1A2 DNA regions of the cytochrome P450 gene. Significant variability in SNPs types was found in 2D6 region. Moreover, haplotyping in 2D6 region showed relatively high occurrences of haplotype 3 and 5 in so-eum person, haplotype 6 in tae-eum person, and hyplotype 1 in so-yang person. These results indicate that individuals with different body constitutions respond differently to ingested food and drugs, which might reflect constitution-specific genetic background. The genetic approach would therefore be useful to reveal intrinsic differences among four constitution body groups in the responsiveness to various drugs and external stimulations to human body.
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KEYWORD
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SNPs, Haplotype, Cytochrome P450
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